LAUSR

was conducted to compare gender-based post diagnosis survival and disease progression. Statistical significance was 95% confidence level (p < 0.05). Result: Among 7738 lung cancer patients, 95.6% (3743/ 7738) were NSCLC: 52% male and 48% female. Significant genderbased differences were observed in histology (p1⁄40.00). SCC and ADC were the most frequent histology in both genders. However, ADC was commoner in women (49% vs 41%), while SCC was commoner in men (27% vs 17%). Relative changes of ADC rate over 15 years have increased significantly among women compared to men (58% vs 32%, P<0.02). The risk of developing NSCLC was greatly elevated with cigarette consumption in both genders; however, ADC in never smokers was higher in women (18%) compared to men (8%). Among ADC, smoking history and gender both showed a significant effect on survival, where mOS for never-smokers females exceeded that of neversmokers males [20 months vs 14 months, 95%CI, P1⁄40.00]. The same trend was also seen in smokers [13 months vs 7 months, 95%CI, P1⁄40.021]. In addition, the OS among male ADC cases was significantly lower than women of all tumor stages (P1⁄40.00), but these disparities were insignificant across genders with SCC (P1⁄40.46). Conclusion: Similar to what we observed in our systematic review, gender influences the clinical course of NSCLC regardless of smoking history or stage in Southern Alberta. Identifying the cause of the increase in ADC rate over 15 years in women and higher prevalence of NSCLC in never smoking women warrants aggressive research strategies.