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P2.16-03 CheckMate 816: A Phase 3 Trial of Neoadjuvant Nivolumab Plus Ipilimumab or Chemotherapy vs Chemotherapy in Early-Stage NSCLC

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exclusion criteria. Seventh TNM edition was used. Totally 168 patients’ demographic data, surgery types, clinical and pathological stage, pre-operative SUVmax and C/T ratio was recorded. Differences between patients with recurrence… Click to show full abstract

exclusion criteria. Seventh TNM edition was used. Totally 168 patients’ demographic data, surgery types, clinical and pathological stage, pre-operative SUVmax and C/T ratio was recorded. Differences between patients with recurrence after surgery and without recurrence was demonstrated. Survival rates were analysed by divided into 3 groups according to C/T ratio (0.25-0.5, 0.5-0.75, 0.75-1.0) and cutoff value 50% of C/T ratio. Result: Two groups (C/T<0.5 and C/ T1⁄40.5-1) did not differ according to comparable factors like visceral pleural invasion, subtype of adenocarcinoma, median SUVmax. Median follow up time was 35 months. 54 patients were died of whom 8 (68%) patients were in C/T ratio<0.5 and 46 patients (67.8%) were in C/T1⁄40.5-1 group. OS was 44.9±5.07 and PFS was 50.8±5.42 in C/ T<0.5 group. OS was 69.7±3.34 and PFS was 77.2±3.23 in C/T1⁄40.5-1 group (p>0.05). Three-year survival rate was 50% for C/T <0.5 and 72% for C/T1⁄40.5-1 group (p>0.05). Mean SUVmax is 8.05±6.04 for C/T<0.5 and 10.07±6.85 for C/T 50% (p1⁄4 0.43). Existence of visceral pleura invasion was higher in patients with C/T 50% (69 patients vs 6 patients, p1⁄40.05). In univariate analyses age, gender and SUVmax value and in multivariate analyses only surgery type and SUV max value were predictors for OS (Surgery type: HR:1.33 (1.04-1.70), p1⁄40.02 and SUVmax: HR:1.04(1.00-1.08), p1⁄40.04).For PFS, only surgery type had significance both unıvariate and multivariate analyses (Univariate: HR: 1.47 (1.15-1.89), p1⁄40.002 and multivariate: HR: 1.67 (1.25-2.23), p1⁄4<0.001). Conclusion: In pathological stage 1 lung adenocarcinomas, SUVmax and surgery type are important predictors for OS. For PFS only surgery type has significance. Even visceral pleura invasion rates are higher in C/T 0.5 group, SUVmax is superior to the C/T ratio for predicting prognosis particularly for solid type lung cancer.

Keywords: surgery type; group; suvmax; type; stage

Journal Title: Journal of Thoracic Oncology
Year Published: 2018

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