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NCI-H460 cells with mutant PIK3CA and KRASgenes. Finally, the effect of radiation on EMT-associated markers was also assessed, revealing that mTORC1 inhibition couldalleviate irradiation-specific EMT changesin NCI-H661 cells. Conclusion: these… Click to show full abstract
NCI-H460 cells with mutant PIK3CA and KRASgenes. Finally, the effect of radiation on EMT-associated markers was also assessed, revealing that mTORC1 inhibition couldalleviate irradiation-specific EMT changesin NCI-H661 cells. Conclusion: these data suggest that mTORC1 inhibition in NSCLC may enhance radiosensitivity by affecting the expression of EMT-associated proteins.This suggests targeting mTORC1 may provide a potential new strategy for the treatment of NSCLC with wildtype PIK3CA and KRAS genes.
Journal Title: Journal of Thoracic Oncology
Year Published: 2018
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