LAUSR

metastasis and recurrence rates. In addition, video-assisted thoracoscopic surgery (VATS) as a less invasive surgical method is widely used for clinical stage I NSCLC during lobectomy, segmentectomy, and wedge resection. Lobectomy is a traditionally gold standard for early stage NSCLC treatment. In recent years, segmentectomy and wedge resection as alternative sublobar resection to lobectomy are recommended. Many studies have indicated that sublobar resection results in equivalent outcomes in patients with stage I NSCLC in comparison with lobectomy, and it is gradually considered that pneumonectomy is unnecessary. However, sublobar resection for NSCLC treatment remains controversial due to an increased risk in local recurrence and poorer long-term survival compared to lobectomy, thus additional local therapy is recommended to patients undergoing sublobar resection.Method: Eligible studies were retrieved from PubMed, Embase, and Cochrane Library. The 1, 2 or 5-year overall survival (OS) and disease-free survival (DFS), and complications rates were used as outcomes indictors. The pooled results for comparison indicators were measured by odds ratios (ORs) with 95% confidence interval (CI) as dichotomous variables. The random effects model was used for all test models in the present study. The consistency assessment in this network meta-analysis was conducted by Node-splitting analysis. Result: A total of 23 studies encompassing 13406 early stage NSCLC patients were included into this network meta-analysis. The results revealed that although 1, 2 and 5-year OS and DFS of lobetomy was superior to segmentectomy and wedge resection, and segmentectomy was better than wedge resection, except for 2-year OS, only result of 5-years OS between groups (wedge resection vs. segmentectomy, OR1⁄4 0.56, 95%CI: 0.36-0.87; wedge resection vs. lobetomy, OR1⁄4 0.51, 95%CI: 0.33-0.79) were significant difference. On the contrary, the complications rate in wedge resection was significant lower than that of lobetomy (lobetomy vs. wedge resection, OR1⁄4 1.73, 95%CI: 1.05-2.72) and segmentectomy (segmentectomy vs. wedge resection, OR1⁄4 1.66, 95%CI: 1.02-2.74), and it was highest in lobetomy. Conclusion: Segmentectomy might be recommended as a reasonable alternative to lobectomy with lower complications rate for early stage NSCLC treatment.