LAUSR

RESULTS: Of 1146 evaluable publications, 51 were included based on above search criteria. WM incidence ranged from 0.3-0.57/100,000 person-years in US studies, with most data showing decreased or stable incidence over time. WM incidence appeared similar in Japan and Taiwan but higher in Sweden (1.05/100,000). Recent data trends suggest significantly increased WM-related survival, though 5-year survival rates vary (52%-78%) in US studies. European data demonstrate similar survival rates and trends (5year survival ~70%) but lower survival in China (61.8%). Across countries, WM appears to be more common in men and in elderly. Mortality rates are also shown to be higher in elderly and male patients. US data suggest higher incidences in Caucasian patients but reduced survival for African American and Hispanic patients. Compared to Westerners, Chinese patients demonstrated a higher maleto-female ratio, younger diagnosis age, higher rates of leukocytopenia, thrombocytopenia, and pancytopenia, and reduced asymptomatic WM. WM-related serious complications are reported, including secondary malignancies, thrombosis, renal diseases, symptomatic hyperviscosity, and autoimmune manifestations. Although novel treatments contribute to improved survival, they significantly increase costs (mean Medicare costs in first treatment year: $9,464 before 2000 to $29,490 after 2008; most recent data available). Data on the humanistic burden of WM are lacking.