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The SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) is essential for virus replication, therefore it is a promising drug target. Here we present a surface plasmon resonance approach to study the interaction… Click to show full abstract
The SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) is essential for virus replication, therefore it is a promising drug target. Here we present a surface plasmon resonance approach to study the interaction of RdRp with drugs in real time. We monitored the effect of favipiravir, ribavirin, sofosbuvir triphosphate PSI-7409 and suramin on RdRp binding to RNA immobilized on the chip. Suramin precluded interaction of RdRp with RNA and even displaced RdRp from RNA.
Keywords:
cov rna;
rna dependent;
rna polymerase;
suramin;
dependent rna;
sars cov
Journal Title: Journal of Virological Methods
Year Published: 2021
Link to full text (if available)
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Journal Title: Journal of Virological Methods
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!