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Parathyroid glands of young adults consist primarily of chief cells. However, with age or after excessive functional stress, another cell type increases progressively-the oxyphil cell. There is evidence for a chief-to-oxyphil… Click to show full abstract
Parathyroid glands of young adults consist primarily of chief cells. However, with age or after excessive functional stress, another cell type increases progressively-the oxyphil cell. There is evidence for a chief-to-oxyphil cell transdifferentiation in chronic kidney disease. The latter may represent a defense mechanism, transforming the actively secreting chief cells to a less actively secreting cell type. However, even if this strategy is able to delay the development of secondary hyperparathyroidism, it cannot prevent it.
Journal Title: Kidney international
Year Published: 2017
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