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Protein-bound uremic toxins (PBUTs) accumulate in chronic kidney disease (CKD) and are poorly removed by dialysis. Gryp et al. demonstrated that fecal bacteria from patients with CKD do not produce more… Click to show full abstract
Protein-bound uremic toxins (PBUTs) accumulate in chronic kidney disease (CKD) and are poorly removed by dialysis. Gryp et al. demonstrated that fecal bacteria from patients with CKD do not produce more PBUTs than do those from healthy controls and that the accumulation of PBUTs, as CKD progresses, is mainly due to their reduced renal elimination by glomerular filtration and tubular secretion. This work underlines the importance of studying the metabolism of PBUTs along the diet-gut-liver-kidney axis.
Keywords:
protein bound;
bound uremic;
uremic toxins;
liver kidney;
gut liver;
kidney
Journal Title: Kidney international
Year Published: 2020
Link to full text (if available)
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Journal Title: Kidney international
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!