LAUSR.org creates dashboard-style pages of related content for over 1.5 million academic articles. Sign Up to like articles & get recommendations!

The anorectic agent, lorcaserin, disturbs estrous cyclicity and produces endometrial hyperplasia without affecting ovarian population in female rats

Photo from wikipedia

Aims: The present study aims to investigate the effect of the new anorectic agent, lorcaserin, on estrous cyclicity, reproductive hormones and folliculogenesis in female mature rats. Materials and methods: Rats… Click to show full abstract

Aims: The present study aims to investigate the effect of the new anorectic agent, lorcaserin, on estrous cyclicity, reproductive hormones and folliculogenesis in female mature rats. Materials and methods: Rats were divided into four groups; Group i: control group. Group ii‐iv: rats treated with lorcaserin (5, 10 or 30 mg/kg/day, p.o.), respectively. The treatment continued for 28 days. Key findings: Lorcaserin (5 or 10 mg/kg) caused estrous cycle disturbance in 40% of treated rats while the high dose (30 mg/kg) produced disturbances in 100% of the treated rats. Lorcaserin (5–30 mg/kg) altered some of female hormones where it enhanced estradiol but reduced luteinizing hormone. Minimal edema with congested vessels was observed in the medulla of ovarian sections. Further, epithelial and uterine sections showed hyperplasia. Significance: Taken together, the present results demonstrated that lorcaserin affected some reproductive hormones, disturbed estrous cyclicity and induced histopathological changes in the ovaries and uteri without affecting the ovarian populations. Therefore, lorcaserin should be used with caution in women of child bearing potential until adequate clinical safety data are available.

Keywords: estrous cyclicity; affecting ovarian; without affecting; cyclicity; anorectic agent; agent lorcaserin

Journal Title: Life Sciences
Year Published: 2017

Link to full text (if available)


Share on Social Media:                               Sign Up to like & get
recommendations!

Related content

More Information              News              Social Media              Video              Recommended



                Click one of the above tabs to view related content.