LAUSR

&NA; Accumulating evidence reveals the association of 1, 3‐dichloro‐2‐propanol (1, 3‐DCP) exposure and lipogenesis. Alliin, the most abundant sulphur compound in garlic, has been demonstrated to exhibit hypoglycemic, antioxidant and anti‐inflammatory activities. Here, we showed that alliin attenuated lipogenesis induced by 1,3‐DCP and that the reduction was due to activation of the AMPK pathway. HepG2 cells exposed to 1,3‐DCP exhibited significant increase of triglyceride(TG) and total cholesterol(TC), and alliin reduced the accumulation. Most importantly, alliin could up‐regulate the phosphorylation of AMPK and down‐regulate protein and gene expressions of SREBP‐1; FAS; SREBP‐2;HMGCR in 1,3‐DCP‐induced HepG2 cells. The results demonstrated that alliin was effective on attenuating 1,3‐DCP‐induced lipogenesis via activation of the AMPK–SREBPs signaling pathway in HepG2 cells. Graphical abstract Figure. No caption available.