LAUSR

BACKGROUND Exposure of particulate matter of <2.5 μm (PM2.5) has been associated with adverse respiratory and the risk of inflammation. While regular physical activity (PA) reduces the risk of many adverse health effects. This study aimed to examine the protection of exercise on adverse pulmonary health induced by PM2.5 exposures in rats. METHODS 80 Wistar rats were randomly divided into 8 groups: Sedentary (S), Exercise (E), Sedentary+ Low concentration PM2.5 exposures (S + LPM), Exercise+Low concentration PM2.5 exposures (E + LPM), Sedentary+Medium concentration PM2.5 exposures (S + MPM), Exercise+ Medium concentration PM2.5 exposures (E + MPM), Sedentary+High concentration PM2.5 exposures (S + HPM), and Exercise+ High concentration PM2.5 exposures (E + HPM). The rats in all E-related groups went through 8-weekaerobic interval treadmill training (5 days/week, 1 h/day). The PM-related groups of rats were exposed to differentconcentrationPM2.5 exposure in Beijing. After one bout of PM exposure, the pulmonary function, structure of lung tissues and several pulmonary biomarkers were observed. RESULTS 1) Compared with S group, following changes occurred in various S + PM2.5 exposure groups: lung tissues were seriously damaged, local bleeding, pus exudation, and inflammatory cell infiltration, as well as the decline of the SOD, CAT and GSH while the incline of Penh, Ti, Te, MDA, TNF-α and IL-1βwere observed. 2) Compared with the corresponding different concentration of S + PM2.5exposure groups, Penh, Ti, Te, MDA, TNF-α and IL-1βwere decreased and CAT and GSH were increased in related E + PM groups respectively. CONCLUSION In summary, the results suggest that acute PM2.5 with different concentrations can cause different degrees of adverse effects on lung, especially in medium and high concentrations. The aerobic interval training improved the pulmonary function and impeded the lesion progression, which is due to effective in impeding the oxidative stress and inflammation.