LAUSR

This study aimed to evaluate the antioxidant capacity of phosphatidylserine liposome (PS) against oxidative stress due to Cyclosporine A (CsA) and their concurrent administration on the attenuation of immune response. The effect of oral PS was evaluated on biochemical and oxidative renal markers and histology of nephrotic rats receiving CsA. The effect of co-administration of PS with CsA was assessed on DTH (delayed-type hypersensitivity) reaction of immunized rats. The cytokine production of IL-2 (Interleukin-2) and IFN-γ (Interferon gamma) was measured in immunized rat's splenocytes. PS treatment significantly (P < 0.05) reduced Cr and BUN of serum and MDA (malondialdehyde) in kidney tissue, and increased SOD (superoxide dismutase) and CAT (Catalase) of kidney tissue in CsA-nephrotic rats. Histopathology indicated significantly (P < 0.05) nephrotoxicity improvement after 25-day treatment with PS. Furthermore, CsA plus PS administration significantly reduced DTH response and cytokine production in immunized rats. In conclusion, co-administration of CsA plus PS may overcome oxidative stress while improving the performance of organ transplantation or autoimmune therapy.