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Clonal evolution revealed by next-generation sequencing in a long-term follow-up patient with hypereosinophilia

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Highlights l Next generation sequencing (NGS) applied to establish clonality in a patient with hypereosinophilia.l The first study reported the clonal evolution in a long-term follow-up patient from CEL-NOS stage… Click to show full abstract

Highlights l Next generation sequencing (NGS) applied to establish clonality in a patient with hypereosinophilia.l The first study reported the clonal evolution in a long-term follow-up patient from CEL-NOS stage to MDS and s-AML.l Disease progression was associated with clonal evolution.

Keywords: clonal evolution; patient hypereosinophilia; next generation; generation sequencing; patient

Journal Title: Leukemia Research Reports
Year Published: 2019

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