LAUSR

Abstract Hybrid nanoparticles (NPs) were designed by adsorbing a (13E,19E)-N1′,N3′-bis[4-(diethylamino)-2-hydroxybenzylidene]malonohydrazide (L) motif, on Fe3O4@SiO2 distorted hexagonal and cubic NPs. Electronic images of the synthesized hybrid NPs revealed distorted topographies with size of ∼50–70 nm. We exploited key in vitro features, topographies, thermal behaviours, spectroscopic data, magnetic properties and heavy metal ion extraction efficiencies of the prepared hybrids. Additionally, the discrete discussion on the surface areas of the synthesized NPs tackled with BET, are introduced. Characterization with FT-IR, SEM, TEM, XRD, BET, VSM, TGA, particle size analysis and Raman spectroscopic techniques revealed that the organic scaffold L is attached to the prepared Fe3O4@SiO2 NPs surface via adsorption or covalent interactions or some sort of charge/proton transfer. Antibacterial tests depicted that, L and Fe3O4@SiO2 NPs exhibited moderate to good antifungal activity against C. albicans, while synthesized key hybrids has shown good to high antibacterial activity against Gram-positive bacterium, S. aureus, two Gram-negative bacteria's, E. coli and P. aeruginosa, and antifungal activity against C. albicans. Also, the Zn2+ ion extraction efficiency of the key hybrids was tackled and validated with commercial pharmaceutical tablet analysis.