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Abstract Titanium possesses mechanical property and excellent biocompatibility but yet suffers from bioinertness and poor osteoblasts adhesion. In this work, minTBP-1 was employed to produce a modified IGF-1 endowed with… Click to show full abstract
Abstract Titanium possesses mechanical property and excellent biocompatibility but yet suffers from bioinertness and poor osteoblasts adhesion. In this work, minTBP-1 was employed to produce a modified IGF-1 endowed with directionality toward Ti surface. It demonstrated that the modified IGF-1 uniformly covered on titanium surface and the surface hydrophilicity was significantly increased. Osteoblasts exhibited increased cell adhesion and mineralization. Our results illustrate that minTBP-1-IGF-1 could produce significant enhancement in osteoblasts adherence, mineralization and maturation.
Journal Title: Materials Letters
Year Published: 2018
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