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Simple preparation of 58S bioactive glass/polycaprolactone composite scaffolds by freeze-drying under ambient conditions

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Abstract Composite scaffolds were successfully obtained using sol-gel derived 58S bioactive glass particles and poly(e-caprolactone) pellets. Camphene was used as the freezing vehicle. No sintering step was used, which represents… Click to show full abstract

Abstract Composite scaffolds were successfully obtained using sol-gel derived 58S bioactive glass particles and poly(e-caprolactone) pellets. Camphene was used as the freezing vehicle. No sintering step was used, which represents a great advantage in terms of energy and time-saving. The prepared scaffolds showed a mechanical behavior similar to elastomeric cellular solids and Young’s modulus of 46.7 ± 9.4 MPa, which may allow their use in load-bearing applications. Cytotoxicity tests revealed that the composites promoted the growth of human osteosarcoma cells. The formation of a hydroxyapatite layer on the surface of the samples was also observed after soaking them in a simulated body fluid solution.

Keywords: bioactive glass; simple preparation; 58s bioactive; preparation 58s; composite scaffolds

Journal Title: Materials Letters
Year Published: 2019

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