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Abstract Strontium-releasing bioactive materials have attracted considerable attention for patients with osteoporotic bone defects due to its ability to stimulate bone formation and decrease bone resorption. In the present study,… Click to show full abstract
Abstract Strontium-releasing bioactive materials have attracted considerable attention for patients with osteoporotic bone defects due to its ability to stimulate bone formation and decrease bone resorption. In the present study, type I collagen/strontium hydroxyapatite nanocomposite (cSrHA) was fabricated via a non-classical biomimetic mineralization pathway. Mineralized collagen fibrils with nanosized SrHA embedded in intrafibrillar interstices were obtained using poly(acrylic acid) as a biomimetic mineralizing director. The resultant nanocomposite was characterized by SEM, TEM, EDS, ATR-FTIR, XRD and TGA. cSrHA displayed morphologies, nanostructures and characteristics similar to those of natural hard tissue and calcium hydroxyapatite-mineralized collagen (cCaHA), indicating its potential value as a biofunctional material for bone engineering.
Journal Title: Materials Letters
Year Published: 2020
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