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PATIENT REPORTED OUTCOMES: GENERAL AND ONCOLOGIC CONSIDERATIONS Patient reported outcomes (PROs) are health-related assessment and feedback that are provided directly by the patient, optimally via standardized and validated tools, and are done so without the aid of an intermediary. As such, PROs may reflect the “voice of the patient” that may be truer as it is not susceptible to what can be “lost in translation.” Patient reported outcomes are increasingly and appropriately emphasized in current paradigms governing the practice of medicine that are founded on patientcentric care and shared decision making. Patient reported outcomes are relevant to and may benefit not only patient care, but also health care policy, medical research, and the search for more effective therapies. In the current issue of Mayo Clinic Proceedings, Warsame and D’Souza provide a scholarly and comprehensive overview of PROs that both outlines the key broad concepts in the field and delineates the specifics and granularity of PROs as they pertain to the subspecialty of oncology. These authors begin with a perspective regarding the development, raison d’être, and current definition of PROs, and how PROs increasingly ramify into diverse fields and disciplines, the latter consideration underscored throughout the review. Warsame and D’Souza discuss how PROs aid in processes that secure approval