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The MEN1 gene encodes MENIN, a tumor suppressor that plays a role in multiple cellular processes. Germline and somatic mutations in MEN1 have been identified in hereditary and sporadic tumors… Click to show full abstract
The MEN1 gene encodes MENIN, a tumor suppressor that plays a role in multiple cellular processes. Germline and somatic mutations in MEN1 have been identified in hereditary and sporadic tumors of neuroendocrine origins suggesting context-specific functions. In this review, we focus on the development of mutational Men1 in vivo models, the known cellular activities of MENIN and efforts to identify vulnerabilities in tumors with MENIN loss.
Keywords:
tissue specific;
menin loss;
specific driver;
driver tumorigenesis;
loss tissue;
loss
Journal Title: Molecular and Cellular Endocrinology
Year Published: 2018
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Journal Title: Molecular and Cellular Endocrinology
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!