LAUSR

espanolLa poliglobulia o eritrocitosis se refiere al aumento de la concentracion de hemoglobina y hematocrito en sangre periferica. La eritropoyetina, producida en un 95% en las celulas renales, es la encargada de la regulacion de la eritropoyesis debido a la hipoxia y se encuentra elevada en las eritrocitosis secundarias. La eritrocitosis primaria mas importante es la policitemia vera, una neoplasia mieloproliferativa cronica que produce eritrocitosis, independientemente de la eritropoyetina, debido a una mutacion de los precursores eritroides. Se establece por un aumento de la hemoglobina superior a 16,5 g/dl en el hombre y 16 g/dl en la mujer. El diagnostico etiologico es fundamental para proporcionar un adecuado manejo al paciente. EnglishPolycythemia or erythrocytosis refers to an increase in hemoglobin and hematocrit concentration in peripheral blood. The erythopoietin, produced in 95% of renal cells, is in charge of erythropoiesis regulation due to hypoxia and is elevated in secondary erythrocytosis. The most important primary erythrocytosis is polycythemia vera, a chronic myeloproliferative neoplasm that produces erythrocytosis independently of erythropoietin due to a mutation in erythroid progenitor cells. A diagnosis is established based on an increase in hemoglobin above 16.5 g/dl in men and 16 g/dl in women. An etiological diagnosis is fundamental for an appropriate management of the patient.