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Biopsy of the sentinel node in lung cancer.

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Abstract Introduction and objective Mediastinal lymph node involvement can be understaged in cases of lung cancer (up to 20% in stage i ). Sentinel node detection is a standard technique… Click to show full abstract

Abstract Introduction and objective Mediastinal lymph node involvement can be understaged in cases of lung cancer (up to 20% in stage i ). Sentinel node detection is a standard technique recommended in breast cancer and melanoma action guidelines, and could also be useful in cases of lung cancer. Material and methods Considering the detection of the sentinel node in non-small cell lung cancer (NSCLC) as feasible, a prospective cohort study was carried out on 48 patients with resectable NSCLC, using the intraoperative injection of colloid sulphate technetium-99. Results The radioisotope migrated in all cases. The procedure's sensitivity was 88.24%, its accuracy was 95.83%, its negative predictive value was 93.94% and the false negative rate was 11.76%. No complications were associated with this technique. Conclusions The detection of a sentinel node in NSCLC with the intraoperative injection of the isotope is feasible and safe, and allows for detection and sensitivity rates comparable to those of other tumor types.

Keywords: cancer; sentinel node; lung cancer

Journal Title: Medicina Clinica
Year Published: 2017

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