LAUSR

Abstract Background and objectives Predominantly antibody deficiencies are the most prevalent primary immunodeficiency (PID) in adults. These are rare diseases difficult to diagnose. Therefore, they are diagnosed late. This study aims to evaluate whether an awareness campaign of PIDs among physicians is associated with an increase in number of diagnoses, a reduction in diagnostic delay and diagnosis at earlier stages. Patients and methods A single centre, interventional, quasi-experimental study was designed that included 2 periods, period 1 pre-intervention (1986–2008) and period 2 post-intervention (2009–2018). A descriptive comparative study of variables was carried out in both periods. Results 116 patients were included [27 (23.3%) in period 1 and 89 (76.7%) in period 2]. The incidence rate increased significantly (0.204 and 1.236/100,000 habs./year; p  Conclusions Given the potentially serious complications of patients with late diagnosis of PIDs, it is necessary to create specialised multidisciplinary units, to unify assistance protocols and to design interventions to increase the knowledge of these entities.