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Multi-dynamic modelling reveals strongly time-varying resting fMRI correlations

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Highlights • MAGE is multi-dynamic in that it models temporal fluctuations in FC independently from fluctuations in the mean of the activity.• MAGE reveals stronger changes in FC over time… Click to show full abstract

Highlights • MAGE is multi-dynamic in that it models temporal fluctuations in FC independently from fluctuations in the mean of the activity.• MAGE reveals stronger changes in FC over time than single-dynamic approaches, such as sliding window correlations.• Multi-dynamic modelling provides an explanation and a solution as to why resting fMRI FC has previously looked so stable.• MAGE models fMRI data as a set of reoccurring brain states, and importantly, these states do not have to be binary and mutually exclusive (e.g., multiple states can be active at one time-point).• MAGE estimated time-varying FC is a better predictor of behavioural variability in the resting-state fMRI data than established methods.

Keywords: time; multi dynamic; time varying; dynamic modelling; resting fmri; mage

Journal Title: Medical Image Analysis
Year Published: 2022

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