LAUSR

Abstract Study objectives The aim of the study was to assay the serum levels of Irisin in women with PCOS. Study design Serum Irisin levels were investigated in obese and normal weight cases with PCOS and in control cases. Study setting The study was done in the Obstetrics and Gynecology Department, Mansoura University, Egypt. Material and methods The study included 80 cases with PCOS and 80 control cases. The patients were stratified by BMI as obese and normal weight. Statistical analysis was performed by using Statistical Package for Social scientists (SPSS) for Windows 7 (SPSS Inc., Chicago, IL, USA). Main outcome measure was to measure the serum Irisin levels in obese and in normal weight cases. Also, some metabolic indices including lipid profile and HOMA-IR were measured in the cases of study. Results Fasting Irisin levels were significantly elevated in obese and in normal weight PCOS patients as compared to the levels in obese and normal weight control women (P = 0.000). The serum Irisin levels in obese and in normal weight PCOS cases were found to be significantly positively correlated with BMI, insulin levels, HOMA-IR, triglycerides levels, and triglycerides/HDL ratio (P  Major conclusion Changes in Irisin levels may be considered as a biomarker for the detection polycystic ovarian syndrome. In the future, it may be used as a marker to follow the disease under various modalities of treatments.