LAUSR

Abstract Introduction Implantation remains the rate-limiting step for the success of in vitro fertilization (IVF). One of the proposed interventions designed to improve endometrial receptivity is physical injury to the endometrium. Aim To determine the effect of endometrial injury done on day 6 of the ICSI cycle on pregnancy rate. Patients & methods Sixty qualified patients undergoing IVF/ICSI were randomized to either endometrial injury on day 6 of the cycle or no intervention. Data about bio-demographic characters, hormonal profile, ultrasound findings and number of oocytes, in addition to, fertilization and pregnancy rates were collected. Results Significant differences were found in favor of day 6 endometrial injury in fertilization, biochemical and clinical pregnancy rates in women undergoing ICSI aged 30 years or less. Conclusion Endometrial injury performed in the proliferative phase of the ICSI cycle increases clinical pregnancy rate; however, further studies are needed to determine the optimum day and site to induce endometrial injury. Pan-African Clinical Trial Registry www.pactr.org Registration number: PACTR201701001968212 .