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Pleiotropic functions of plasmacytoid dendritic cells in the pathogenesis of the rheumatoid arthritis.

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Rheumatoid arthritis is a chronic autoimmune inflammatory disease with an unclear etiology. The disease is characterized by infiltration of synovial tissue with immune cells, among which there are dendritic cells… Click to show full abstract

Rheumatoid arthritis is a chronic autoimmune inflammatory disease with an unclear etiology. The disease is characterized by infiltration of synovial tissue with immune cells, among which there are dendritic cells that play multifaceted roles in the pathogenesis of the disease. Here we shall assume that plasmacytoid dendritic cells are able to change their phenotype under the influence of various stimuli, thereby modulating the course of the disease, contributing to both the development of exacerbations and the induction of remissions depending on the phenotype they have acquired. This property can be used to develop new methods of immunotherapy.

Keywords: disease; pathogenesis; dendritic cells; plasmacytoid dendritic; rheumatoid arthritis

Journal Title: Medical hypotheses
Year Published: 2019

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