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Abstract SARS-CoV-2 virus has resulted in a devastating pandemic of COVID-19.Exploring compounds that could offer a breakthrough in treatment is the need of the hour. Re-positioning cheap, freely available and… Click to show full abstract
Abstract SARS-CoV-2 virus has resulted in a devastating pandemic of COVID-19.Exploring compounds that could offer a breakthrough in treatment is the need of the hour. Re-positioning cheap, freely available and safe drugs is a priority. The paper proposes evidence for the potential use ofdiethylcarbamazine (DEC) in the treatment of COVID-19. DEC hasinhibitory effects onarachidonic acid metabolism to prostaglandins,little knownanti-viral effects on animal retroviruses and demonstratedanti-inflammatory actions inanimal models of lung inflammation indicating the need to explore this hypothesis further. We believe this is the first time DEC is being proposed to treat COVID-19.
Journal Title: Medical hypotheses
Year Published: 2020
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