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The herein synthesized 7-(4-methylphenyl)thiomethyl and 7-morpholylmethyl derivatives of natural phaeosphaeride A have lower cytotoxic activity towards the human lung adenocarcinoma A549 cell line compared to phaeosphaeride A. The presence of… Click to show full abstract
The herein synthesized 7-(4-methylphenyl)thiomethyl and 7-morpholylmethyl derivatives of natural phaeosphaeride A have lower cytotoxic activity towards the human lung adenocarcinoma A549 cell line compared to phaeosphaeride A. The presence of exocyclic C=C bond and N–OMe group in such compounds is suggested to be a factor in their antitumor activity.
Keywords:
methylphenyl thiomethyl;
derivatives natural;
natural phaeosphaeride;
activity;
thiomethyl morpholylmethyl;
morpholylmethyl derivatives
Journal Title: Mendeleev Communications
Year Published: 2017
Link to full text (if available)
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Journal Title: Mendeleev Communications
Year Published: 2017
Link to full text (if available)
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recommendations!