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A new stereoselective synthesis of biologically active di- and trienoic acids containing a (1Z,5Z)-diene moiety

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Natural (5Z,9Z)-dienoic acids and key precursors of biologically active trienoic acids were prepared in high yields and with high stereoselectivity using cross-cyclomagnesiation of terminal and oxygenated 1,2-dienes with EtMgBr in… Click to show full abstract

Natural (5Z,9Z)-dienoic acids and key precursors of biologically active trienoic acids were prepared in high yields and with high stereoselectivity using cross-cyclomagnesiation of terminal and oxygenated 1,2-dienes with EtMgBr in the presence of Mg metal and Cp2TiCl2 catalyst at the key step.

Keywords: stereoselective synthesis; active trienoic; new stereoselective; biologically active; trienoic acids

Journal Title: Mendeleev Communications
Year Published: 2017

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