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Biodegradable liposome–chitosan complexes: enzyme-mediated release of encapsulated substances

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Multi-liposomal containers were prepared via electrostatic adsorption of 50 nm anionic liposomes on the surface of cationic chitosan nanoparticles (nanogels) 270 nm in diameter. The containers are stable in aqueous-salt… Click to show full abstract

Multi-liposomal containers were prepared via electrostatic adsorption of 50 nm anionic liposomes on the surface of cationic chitosan nanoparticles (nanogels) 270 nm in diameter. The containers are stable in aqueous-salt solutions but degrade in the presence of proteolytic enzymes down to 10–15 nm particles and release water-soluble substances encapsulated into the adsorbed liposomes. Based on the kinetic data, the mechanism of the release is discussed.

Keywords: complexes enzyme; liposome chitosan; biodegradable liposome; chitosan; chitosan complexes; release

Journal Title: Mendeleev Communications
Year Published: 2018

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