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A convenient approach to novel symmetric bispyrimidine diamines comprises SNAr reactions of 4-fluoropyrimidine N-oxide with alkane-α,ω-diamines with subsequent reduction of N-oxide function. The obtained substances were tested in patch-clamp experiments… Click to show full abstract
A convenient approach to novel symmetric bispyrimidine diamines comprises SNAr reactions of 4-fluoropyrimidine N-oxide with alkane-α,ω-diamines with subsequent reduction of N-oxide function. The obtained substances were tested in patch-clamp experiments for the influence on the kainateinduced currents in Purkinje neurons and showed negative modulating effect.
Keywords:
negative modulators;
modulators based;
receptor negative;
ampa receptor;
first ampa;
based tetrahydroquinazoline
Journal Title: Mendeleev Communications
Year Published: 2018
Link to full text (if available)
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Journal Title: Mendeleev Communications
Year Published: 2018
Link to full text (if available)
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recommendations!