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A catalyst-free one-step synthesis of N-pyrimidinyl amidines from endocyclic enamines and 4-azidopyrimidines

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Novel N-pyrimidyl amidines of alycyclic acids were obtained in one step from of 4-azidopyrimidines and endocyclic enamines. The reaction mechanism involves [3 + 2]-addition of azide at the double bond… Click to show full abstract

Novel N-pyrimidyl amidines of alycyclic acids were obtained in one step from of 4-azidopyrimidines and endocyclic enamines. The reaction mechanism involves [3 + 2]-addition of azide at the double bond followed by cleavage of thus formed 1,2,3-triazoline ring, and a contraction of alicycle.

Keywords: endocyclic enamines; step synthesis; free one; catalyst free; one step

Journal Title: Mendeleev Communications
Year Published: 2019

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