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Available NH-2-acylethynylpyrroles undergo annulation/aromatization with propargylamine in the presence of 1 equiv. of CuHal (Hal = Cl, Br, I) at 60–65 °C to afford 3-acyl-2-(pyrrol-2-yl)pyridines and their 5-halo analogues in 28–61 and 5–14%… Click to show full abstract
Available NH-2-acylethynylpyrroles undergo annulation/aromatization with propargylamine in the presence of 1 equiv. of CuHal (Hal = Cl, Br, I) at 60–65 °C to afford 3-acyl-2-(pyrrol-2-yl)pyridines and their 5-halo analogues in 28–61 and 5–14% yields, respectively. The latter are assumed to be resulted from halohydrogenation of the intermediate Cu-pyrrolylpropargyl amino enones.
Keywords:
formation acyl;
promoted formation;
halide promoted;
copper halide;
halopyridine moiety;
acyl halopyridine
Journal Title: Mendeleev Communications
Year Published: 2019
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Journal Title: Mendeleev Communications
Year Published: 2019
Link to full text (if available)
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recommendations!