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For the development of new antitumor agents, novel dibenzo-1,7-diaza-14-crown-4 ethers containing γ-piperidone moiety were synthesized by a domino condensation of new podands, ketones and ammonium acetate. The crystal structure of… Click to show full abstract
For the development of new antitumor agents, novel dibenzo-1,7-diaza-14-crown-4 ethers containing γ-piperidone moiety were synthesized by a domino condensation of new podands, ketones and ammonium acetate. The crystal structure of one Ts of them was studied by X-ray diffraction. Four crown compounds were evaluated in vitro for cytotoxic activity against 5 human cancer cell lines.
Keywords:
crown ethers;
synthesis cytotoxicity;
dibenzo diaza;
piperidone;
diaza crown;
crown
Journal Title: Mendeleev Communications
Year Published: 2019
Link to full text (if available)
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Journal Title: Mendeleev Communications
Year Published: 2019
Link to full text (if available)
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recommendations!