The Petasis–Mannich reaction of allenylboronic acid with glyoxylic acid and (S)-1-phenylethylamine diastereoselectively leads to N-substituted propargylglycine of high optical purity in good yield. This product can be further subjected to… Click to show full abstract
The Petasis–Mannich reaction of allenylboronic acid with glyoxylic acid and (S)-1-phenylethylamine diastereoselectively leads to N-substituted propargylglycine of high optical purity in good yield. This product can be further subjected to esterification followed by bioconjugate synthesis using CuI-catalyzed alkyne–azide 1,3-dipolar cycloaddition reaction (‘click reaction’).
Keywords:
allenylboronic acid;
propargylglycine;
stereoselective synthesis;
synthesis propargylglycine;
efficient stereoselective
Journal Title: Mendeleev Communications
Year Published: 2019
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Journal Title: Mendeleev Communications
Year Published: 2019
Link to full text (if available)
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recommendations!