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The title compound, as the new chiral building block for bioactive cyclopentenones, was prepared in 8 steps with 15% overall yield. The key steps involve selective homologation in intermediate [(1S,2R,5R)-5-trimethysilylcyclopent-3-ene-… Click to show full abstract
The title compound, as the new chiral building block for bioactive cyclopentenones, was prepared in 8 steps with 15% overall yield. The key steps involve selective homologation in intermediate [(1S,2R,5R)-5-trimethysilylcyclopent-3-ene- 1,2-diyl]dimethanol by regioselective silylation followed by oxidation and the Wittig reaction.
Keywords:
7ar tetrahydrocyclopenta;
convenient synthesis;
enantiopure 4as;
synthesis enantiopure;
tetrahydrocyclopenta pyran;
4as 7ar
Journal Title: Mendeleev Communications
Year Published: 2020
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Journal Title: Mendeleev Communications
Year Published: 2020
Link to full text (if available)
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recommendations!