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Synthesis of 6-[4-methoxy-3-(pyrrolidin-1-ylmethyl)benzyl]-1,11-dimethyl-3,6,9-triazatricyclo[7.3.1.13,11]tetradecane-4,8,12-trione has been carried out and optimized. In vitro studies using electrophysiological patch clamp technique have revealed a negative effect of this compound on kainateinduced currents in Purkinje… Click to show full abstract
Synthesis of 6-[4-methoxy-3-(pyrrolidin-1-ylmethyl)benzyl]-1,11-dimethyl-3,6,9-triazatricyclo[7.3.1.13,11]tetradecane-4,8,12-trione has been carried out and optimized. In vitro studies using electrophysiological patch clamp technique have revealed a negative effect of this compound on kainateinduced currents in Purkinje neurons in a wide range of concentrations from 10−11 to 10−6 m.
Keywords:
allosteric modulator;
modulator ionotropic;
glutamate receptors;
ionotropic glutamate;
synthesis allosteric
Journal Title: Mendeleev Communications
Year Published: 2020
Link to full text (if available)
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Journal Title: Mendeleev Communications
Year Published: 2020
Link to full text (if available)
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recommendations!