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New polyfunctional hydrogenated pyrido[1,2-a]pyrazin- 1-ones were obtained by regioselective recyclization of N-arylitaconimides with alkyl (3-oxopiperazin-2-ylidene)acetates. The supposed cascade reaction pathway involves the Michael addition of the nucleophile to an activated… Click to show full abstract
New polyfunctional hydrogenated pyrido[1,2-a]pyrazin- 1-ones were obtained by regioselective recyclization of N-arylitaconimides with alkyl (3-oxopiperazin-2-ylidene)acetates. The supposed cascade reaction pathway involves the Michael addition of the nucleophile to an activated double bond and subsequent intramolecular transamidation of the intermediate with simultaneous recycling.
Keywords:
pyrido pyrazin;
new polyfunctional;
efficient synthesis;
pyrazin ones
Journal Title: Mendeleev Communications
Year Published: 2021
Link to full text (if available)
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Journal Title: Mendeleev Communications
Year Published: 2021
Link to full text (if available)
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recommendations!