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Abstract Rare cis-configured 2,4-disubstituted 1-alkylpyridines were envisioned as ligands for trace amine associated receptor 1 (TAAR1). They were synthesized in diastereomerically pure form with the decarboxylative Castagnoli–Cushman reac-tion followed by… Click to show full abstract
Abstract Rare cis-configured 2,4-disubstituted 1-alkylpyridines were envisioned as ligands for trace amine associated receptor 1 (TAAR1). They were synthesized in diastereomerically pure form with the decarboxylative Castagnoli–Cushman reac-tion followed by two reduction events. Despite showing no affinity to TAAR1 as was anticipated, these novel, druglike and CNS-focused compounds will be of much utility in sub-sequent lead generation pursuits.
Keywords:
cis configured;
rare cis;
trace amine;
taar1;
configured disubstituted;
amine associated
Journal Title: Mendeleev Communications
Year Published: 2021
Link to full text (if available)
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Journal Title: Mendeleev Communications
Year Published: 2021
Link to full text (if available)
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recommendations!