LAUSR

Septal junctions are cell-cell connections that mediate intercellular communication in filamentous cyanobacteria. The septal peptidoglycan is perforated by dozens of 20 nm-wide nanopores, through which these proteinaceous structures traverse, physically connecting adjacent cells. On each cytoplasmic side, every septal junction contains a flexible cap structure that closes the connection in a reversible manner upon stress. This gating mechanism reminds of the gap junctions from metazoans and represents a primordial control system for cell-cell communication. In this review, we summarize the knowledge about formation of the nanopore array as the framework for incorporation of cell-cell connecting septal junctions. Furthermore, the architecture of septal junctions, proteins involved in septal junction constitution and regulation of intercellular communication will be addressed.