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Evolution of the hygiene hypothesis into biota alteration theory: what are the paradigms and where are the clinical applications?

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For thousands of years, changes in human cultures have altered the biota associated with the human body, and those alterations have strongly influenced human health. The hygiene hypothesis has evolved… Click to show full abstract

For thousands of years, changes in human cultures have altered the biota associated with the human body, and those alterations have strongly influenced human health. The hygiene hypothesis has evolved over the past 30 years into a nuanced biota alteration theory, but modern medical priorities and regulatory policies have resulted in tragic underutilization of the acquired knowledge.

Keywords: hygiene hypothesis; alteration theory; biota alteration

Journal Title: Microbes and infection
Year Published: 2018

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