LAUSR

Abstract Nickel nanowrinkles were synthesized by a simple hydrothermal method in one step in the presence of fluoride ions in ethylene glycol. The nanowrinkles were then employed as the modifier of a carbon paste electrode. The kinetics of the charge transfer across the modified electrode/solution interface was studied and the modified electrode was employed to fabricate an amperometric sensor of hydrochlorothiazide. The mechanism and kinetics of the electrocatalytic oxidation of hydrochlorothiazide on the modified electrode surface were studied by cyclic voltammetry and chronoamperometry. An amperometric procedure was developed for determination of hydrochlorothiazide with a sensitivity of 13.50 mA mol− 1 dm3 cm− 2 and a limit of detection of 21.2 μmol dm− 3. The method was used for the direct assay of hydrochlorothiazide in human serum samples and hydrochlorothiazide tablets. The sensor had the advantages of sensitivity (guaranteed by a Nafion layer on the sensor surface), high electrocatalytic activity and long-term stability toward hydrochlorothiazide.