LAUSR

Abstract The electrochemical behavior of antiretroviral drug, nevirapine (NVP), was investigated using the glassy carbon electrode modified with carboxylated multi-walled carbon nanotubes and synthesized with 11-mercaptoundecanoyl hydrazinecarbothioamide coated silver nanoparticles (MUHC-AgNPs/c-MWCNTs/GCE). The surface of the modified electrode was characterized by cyclic voltammetry (CV), scanning electron microscopy (SEM) and electrochemical impedance spectroscopy (EIS). The synthesized silver nanoparticles decorated by MUHC in the presence of c-MWCNTs increased the current response of GCE toward NVP electro-oxidation. In the concentration range of 50 nM to 21 μM of NVP with a detection limit of 14 nM and limit of quantification (LOQ) of 46.7 nM, a linear response was achieved over optimized conditions in 0.01 M NaOH solution. The amperometry technique was applied at a constant potential of 0.67 V in stirred solutions. The proposed amperometric sensor was successfully used for NVP determination in spiked human serum and tablet.