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spite of sequence divergence. We are currently identifying functional transcription factor binding sites in endodermal enhancers in both species to identify conserved upstream regulators shared between Phallusia and Ciona. Taken… Click to show full abstract
spite of sequence divergence. We are currently identifying functional transcription factor binding sites in endodermal enhancers in both species to identify conserved upstream regulators shared between Phallusia and Ciona. Taken together our results suggest that extensive transcription factor binding site turn over, without radical change in GRNs architecture, may explain the qualitative conservation of gene expression patterns between highly divergent ascidian genomes.
Keywords:
mouse models;
lrp2 deficient;
deficient mouse;
holoprosencephaly phenotypes;
models strongly;
phenotypes lrp2
Journal Title: Mechanisms of Development
Year Published: 2017
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Journal Title: Mechanisms of Development
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!