LAUSR

non-myelinating Schwan precursor cells in neural crest maintenance medium. Cells also partially expressed mesenchymal stem cells markers and developed into mature mesenchymal lineages including osteocyte, chondrocyte and adipocyte under each appropriate condition. In order to evaluate the differentiation potential in vivo, the LNGFR (+) THY-1 (+) cells were injected into the chick embryo and the humanized immunodeficient adult mice. Transplanted LNGFR (+) THY-1 (+) cells survived in vivo, and they can generate the various types of mature cells. The present study shows that human iPS cells-derived LNGFR (+) THY-1 (+) cells have multipotent differentiation ability in vitro, and migration and environmental adaptation capacity in vivo. Taken together, these results suggest that LNGFR (+) THY-1 (+) identified following neural crest-like cells induction from iPS cells shared potentials with multipotent MSCs.