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ER Stress Promotes Inflammation through Re-wIREd Macrophages in Obesity.

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A new mechanism linking ER dysfunction to metabolic inflammation is discovered in a recent study by Shan et al. (2017), which demonstrated ER stress-induced rewiring of adipose tissue macrophage polarization by… Click to show full abstract

A new mechanism linking ER dysfunction to metabolic inflammation is discovered in a recent study by Shan et al. (2017), which demonstrated ER stress-induced rewiring of adipose tissue macrophage polarization by IRE1α activation, leading to impaired systemic glucose homeostasis.

Keywords: wired macrophages; stress promotes; inflammation; inflammation wired; stress; promotes inflammation

Journal Title: Molecular cell
Year Published: 2017

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