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Cancer Mutations in SPOP Put a Stop to Its Inter-compartmental Hops.

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In this issue of Molecular Cell, Bouchard et al. (2018) identify liquid-liquid phase separation as a mechanism for substrate-triggered localization of SPOP and ubiquitination machinery to different nuclear bodies and describe… Click to show full abstract

In this issue of Molecular Cell, Bouchard et al. (2018) identify liquid-liquid phase separation as a mechanism for substrate-triggered localization of SPOP and ubiquitination machinery to different nuclear bodies and describe how cancer mutations disrupt this process.

Keywords: cancer mutations; mutations spop; put stop; spop put; cancer; stop inter

Journal Title: Molecular cell
Year Published: 2018

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