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In this issue of Molecular Cell, Byun et al. (2020) find that the dual targeting of glutamine metabolism and the PD-L1 checkpoint inhibitor augments anti-tumor immunity. Mechanistically, decreased glutamine availability attenuated… Click to show full abstract
In this issue of Molecular Cell, Byun et al. (2020) find that the dual targeting of glutamine metabolism and the PD-L1 checkpoint inhibitor augments anti-tumor immunity. Mechanistically, decreased glutamine availability attenuated S-glutathionylation of SERCA, resulting in an increase in cytosolic calcium, enhanced NF-κB activity, and upregulation of programmed death-ligand 1.
Keywords:
glutamine metabolism;
anti tumor;
targeting glutamine;
metabolism novel
Journal Title: Molecular cell
Year Published: 2020
Link to full text (if available)
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Journal Title: Molecular cell
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!