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Igelmann et al. report a novel metabolic cycle, which they name HTC, that converts NADH into the key antioxidant factor NADPH. The HTC is repressed by the tumor suppressors p53 and… Click to show full abstract
Igelmann et al. report a novel metabolic cycle, which they name HTC, that converts NADH into the key antioxidant factor NADPH. The HTC is repressed by the tumor suppressors p53 and RB, and this determines whether oncogene-expressing cells undergo senescence (HTCoff) or malignant transformation (HTCon).
Keywords:
diverts cells;
senescence;
cycle;
cycle diverts;
redox cycle;
novel redox
Journal Title: Molecular cell
Year Published: 2021
Link to full text (if available)
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Journal Title: Molecular cell
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!