LAUSR

HighlightsThe combination of cryoablation, NK cells, and Herceptin has good efficacy for HER2 overexpressing recurrent breast cancer.Combinations therapy improves QOL and PFS and reduces CEA, CA15‐3, and CTC expression.Combination therapy enhances the immune function of patients. ABSTRACT In this study, we investigated the clinical benefits of a combination of tumor cryoablation with natural killer (NK) cells therapy and Herceptin for human epidermal growth factor (HER) 2‐overexpressing recurrent breast cancer. From May 2015 to May 2016, 48 patients who met the enrollment criteria were assigned to three groups (n = 16): cryoablation group (group I), cryoablation‐NK cells therapy group (group II) and cryoablation‐NK cells therapy‐Herceptin group (group III). Safety and short‐term effects were evaluated. All the adverse effects were manageable and acceptable. The three‐therapy combination treatment not only yielded good clinical efficacy, it also improved the quality of life; reduced levels of circulating tumor cells (CTCs); reduced carcino‐embryonic antigen (CEA) and cancer antigen 15‐3 (CA15‐3) expression; enhanced immune function significantly. Furthermore, it can resulte in significant prolongation of progression free survival (PFS). This is the first clinical study to demonstrate the benefit of the three‐therapy combination of tumor cryoablation, NK cells therapy, and Herceptin for HER2‐overexpressing recurrent breast cancer.